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Graduate School of Chemical and Molecular Sciences Zurich

Organometallic Chemistry

Synthesis of Complex Molecules and Late Transition Metal Catalysis

Central to our interest is the total synthesis of natural products with challenging architectures and relevant biological properties. Our driving force stems from the discovery and application in synthesis of new methodologies based on late transition metal catalyzed reactions. Supported on high level theoretical calculations and biological assays we want to get a deeper insight into the structure-activity relationships (SAR) of these molecules. At the same time, we aim to provide flexible chemical methods that allow structural modifications in order to improve their therapeutic profiles. A complete palette of the most advance experimental tools is found in our lab. Classic and novel methodologies applied in chemical syntheses, parallel techniques, GC and HPLC expertise, NMR analysis, computational studies in living models, in combination with biological assays are offered to the students to provide an interdisciplinary background in the wide area of Organic Chemistry.
The following endeavours fuel our efforts:
♦ Total Synthesis of Complex Natural Products
♦ Modular Synthesis of “Small Molecules” with Interesting Biological Properties
♦ Understanding and Tuning the Subtleties of Bioactivity: Computational Studies and Biological Assays
♦ New C-H Functionalization Reactions Based on Gold (III)-Complexes
♦ New C-C and C-X Forming Reactions Catalyzed by Late Transition Metals (Pt, Au)

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