Flow Chemistry and Chemical Biology

Our research interests at the interface of organic chemistry, automated flow synthesis and chemical biology center on the synthesis and application of natural and artificial biopolymers.

Sequence-defined polymers, including peptides and proteins, play crucial roles in every aspect of life. Their chemical synthesis allows for the incorporation of non-canonical amino acids, post-translational modifications, modified backbones and functional handles, but requires highly efficient transformations for the incorporation of every single building block. We use flow chemistry to develop new reactions, synthesize non-natural building blocks and to ultimately provide tailored proteins and related functional polymers on demand.