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Graduate School of Chemical and Molecular Sciences Zurich

Publication List


  1. “Rapid Flow-Based Synthesis of Post-Translationally Modified Peptides and Proteins: A Case Study on MYC’s N-terminus”
    E. T. Williams, K. Schiefelbein, M. Schuster, I. M. M. Ahmed, M. De Vries, R. Beveridge, O. Zerbe, N. Hartrampf*
    Manuscript submitted for publication
    ChemRxiv 2024,
  2. “Probing PAC1 receptor activation across species with an engineered sensor”
    R. B. Cola, S. N. Niethammer, P. Rajamannar, A. Gresch, M. A. Bhat, K. Assoumou, E. T. Williams, P. Hauck, N. Hartrampf, D. Benke, M. Stoeber, G. Levkowitz, S. Melzer, T. Patriarchi*
    Manuscript submitted for publication
    BioRxiv 2024,
  3. “A robust data analytical method to investigate sequence-dependence in flow-based peptide synthesis”
    B. Tamás,‡ P.L. Willi,‡ H. Bürgisser, N. Hartrampf*
    (‡ = equal contributions)
    React. Chem. Eng. 2024,   Advanced Article (Emerging Investigator Series)
  4. “A versatile “Synthesis Tag” (SynTag) for the chemical synthesis of aggregating peptides and proteins”
    H. Bürgisser,‡ E. T. Williams,‡ R.Lescure, A. Premanand, A. Jeandin, N. Hartrampf*
    (‡ = equal contributions)
    ChemRxiv 2023
  5. “Optical tools for visualizing and controlling human GLP-1 receptor activation with high spatiotemporal resolution”
    L. Duffet,‡ E. T. Williams,‡ A. Gresch, S. Chen, M. A Bhat, D. Benke, N. Hartrampf,* T. Patriarchi*
    (‡ = equal contributions)
    eLife 2023,  12:RP86628.
  6. “A photocaged orexin-B for spatiotemporally precise control of orexin signaling”
    L. Duffet,‡ P. V. Tatarskiy,‡ M. Harada,‡ E. T. Williams, N. Hartrampf,* T. Patriarchi*
    (‡ = equal contributions)
    Cell Chem. Bio 2022, 29, 1729.
  7. “Flow-Based Methods in Chemical Peptide and Protein Synthesis”
    K. Schiefelbein, N. Hartrampf*
    CHIMIA 2021, 75, 480.
  8. “Flow-based SPPS for protein synthesis: A perspective”
    Z. P. Gates,* N. Hartrampf*
    Pept. Sci. 2020, e24198.

Postdoctoral, Graduate, and Undergraduate Research

  1. "Structural Diversity of Photoswitchable Sphingolipids for Optodynamic Control of Lipid Raft Microdomain"
    N. Hartrampf,‡ S. M. Leitao,‡ N. Winter, H. Toombs-Ruane, J. A. Frank, P. Schwille, D. Trauner, H. G. Franquelim
    (‡ = authors contributed equally)
    Biophys. J. 2023, 122, 11, 2325–2341.
  2. “Rapid Single-Shot Synthesis of the 217 Amino Acid-Long N-Terminal Domain of Pyocin S2”
    A. Saebi,‡ J. S. Brown,‡ V. M., Marando, N. Hartrampf, N. M. Chumbler, S. Hanna, M. Poskus; A. Loas, L. L. Kiessling, D. T. Hung, B. L. Pentelute*
    (‡ = authors contributed equally)
    ACS Chem. Biol. 2023, 18, 3, 518–527.
  3. "A Tumor-Homing Peptide Platform enhances Drug Solubility, Improves Blood-Brain Barrier Permeability and Targets Glioblastoma"
    C.-F. Cho,* C. E. Farquhar, C. M. Fadzen, B. Scott, P. Zhuang, N. v. Spreckelsen, A. Loas, N. Hartrampf, B. L. Pentelute, S. E. Lawler
    Cancers 2022, 14, 2207.
  4. “Automated Flow Synthesis of Peptide-PNA Conjugates”
    C. Li, A. J. Callahan, K.-S. Phadke, B. Bellaire, C. E. Farquhar, G. Zhang, C. K. Schissel, A. J. Mijalis, N. Hartrampf, A. Loas, D. E. Verhoeven, B. Pentelute*
    ACS Cent. Sci 2022, 8, 2, 205.
  5. "Fully Automated Fast-Flow Synthesis of Antisense Phosphorodiamidate Morpholino Oligomers"
    C. Li, A. J. Callahan, M. D. Simon, K. A. Totaro, A. J. Mijalis, N. Hartrampf, C. K. Schissel, M. Zhou, H. Zong, Gunnar J. Hanson, A. Loas, N. L. B. Pohl, B. L. Pentelute
    ( = authors contributed equally)
    Nat. Commun. 2021, 12, 4396
  6. Targeting glioblastoma using a novel peptide specific to a deglycosylated isoform of brevican
    N. v. Spreckelsen, C. M. Fadzen, N. Hartrampf, Y. Ghotmi, J. M. Wolfe, S. Dubey, B. Y. Yang, M. F. Kijewski, S. Wang, C. Farquhar, S. Bergmann, M. Zdioruk, J. R. Wasserburg, B. Scott, E. Murrell, F. C. Bononi, L. G. Luyt, M. DiCarli, M. L. M. Lamfers, K. L. Ligon, E. A. Chiocca, M. S. Viapiano, B. L. Pentelute, S. E. Lawler, C.-F. Cho
    Adv. Ther. 2021, 4, 2000244
  7. Identification of N-terminally diversified GLP-1R agonists using saturation mutagenesis and chemical design
    C. K. Longwell, S. Hanna, N. Hartrampf, R. A. Parra Sperberg, P.-S. Huang, B. L. Pentelute, J. R. Cochran
    ACS Chem. Biol. 2021, 16, 1, 58–66
  8. Deep Learning for Prediction and Optimization of Fast-Flow Peptide Synthesis
    S. Mohapatra, N. Hartampf, M. Poskus, R. Gomez-Bombarelli, B. L. Pentelute
    ( = authors contributed equally)
    ACS Cent. Sci. 2020, 6, 2277–2286
  9. Ultra-large chemical libraries for the discoveryof high-affinity peptide binders
    A. J. Quartararo, Z. P. Gates, B. A. Somsen, N. Hartrampf, X. Ye, A. Shimada, Y. Kajihara, C. Ottmann, B. L. Pentelute
    Nat. Commun. 2020, 11, 3183
  10. Synthesis of Proteins by Automated Flow Chemistry
    N. Hartrampf, A. Saebi, M. Poskus, Z. P. Gates, A. J. Callahan, A. E. Cowfer, S. Hanna, S. Antilla, C. K. Schissel, A. J. Quartararo, X. Ye, A. J. Mijalis, M. D. Simon, A. Loas, S. Liu, C. Jessen, T. E. Nielsen, B. L. Pentelute ( = authors contributed equally)
    Science , 2020, 368, 980-987 
    This work was highlighted by others in:
    • Science Perspective: C. Proulx, Science 2020, 368, 941
    • Synfacts: D. Trauner, B. S. Matsuura, Synfacts2020 , 16, 1129 (selected as “Synfact of the month”)
    MIT News, Chemistry World, CE&N and others.
  11. “Immune-Modulating Photochromic Galactosyl Ceramides allow for Optical Control of Cytokine Production”
    N. Hartrampf, T, Seki, A. Baumann, P. Watson, N. A. Veprek, B. Hetzler, A. Hoffmann-Röder, M. Tsuji, D. Trauner
    Chem. Eur. J. 2020, 26, 4476-4479
  12. Total Synthesis of the Norhasubanan Alkaloid Stephadiamine
    N. Hartrampf, N. Winter, G. Pupo, B. Stoltz, D. Trauner
    J. Am. Chem. Soc. 2018, 140, 8675–8680.
    Highlighted in Synfacts: E. M. Carreira, F. Pultar, Synfacts 2018, 14, 0898 
  13. Light control of L-type Ca2+ channels using a diltiazem photoswitch
    T. Fehrentz, F. M. E. Huber, N. Hartrampf, T. Bruegmann, J. A. Frank, N. H.F. Fine, D. Malan, J. G. Danzl, D. B. Tikhonov, M. Sumser, P. Sasse, D. J. Hodson, B. S. Zhorov, N. Klöcker, D. Trauner
    Nat. Chem. Biol. 2018, 14, 764–767. 
  14. "Synthetic Approaches towards Alkaloids Bearing α-Tertiary Amines"
    A. Hager, N. Vrielink, D. Hager, J. Lefranc, D. Trauner ( = authors contributed equally)
    Nat. Prod. Rep. 2016, 33, 491–522. 
  15. "Targeting a Dynamic Protein–Protein Interaction: Fragment Screening against the Malaria Myosin A Motor Complex"
    C. H. Douse, N. Vrielink, Z. Wenlin, E. Cota, E. W. Tate
    ChemMedChem, 2015, 10, 134-143. 

Perspectives and Conference Reports

“Peptide Therapeutics Forum 2023”
N. Hartrampf
CHIMIA 2023, 77, 877–878.

“Reflections on Navigating a Pandemic: Perspectives from the Chemical Biology Community” (Editorial for the ChemBioTalents special issue)
A. C. Conibear, N. Hartrampf
ChemBioChem 2023, e202300258.

“An Active Member of the EFMC: The Division of Medicinal Chemistry and Chemical Biology of the Swiss Chemical Society”
Y. P. Auberson,* F. Benfatti, D. Gillingham, N. Hartrampf
ChemMedChem 2023, 18, e202300014.

“DMCCB Basel Symposium 2022 - Intrinsically Disordered Proteins as Drug Targets”
E. T. Williams, N. Hartrampf*
CHIMIA 2022, 76, 493.

“The Young Faculty Meeting 2021 - A Focus on Group Management”
J. de Roo, N. Hartrampf, L. Merz
CHIMIA 2021, 75, 692–694.

"Protein Chemistry Looking Ahead: 8th Chemical Protein Synthesis Meeting 16-19 June 2019, Berlin, Germany
C. Bello, N. Hartrampf, L. J. Walport, A. C. Conibear
Cell Chem. Biol. 2019, 26, 1349–1354.