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Our research interests at the interface of organic chemistry, automated flow synthesis and chemical biology center on the synthesis and application of natural and artificial biopolymers.
Sequence-defined polymers, including peptides and proteins, play crucial roles in every aspect of life. Their chemical synthesis allows for the incorporation of non-canonical amino acids, post-translational modifications, modified backbones and functional handles, but requires highly efficient transformations for the incorporation of every single building block. We use flow chemistry to develop new reactions, synthesize non-natural building blocks and to ultimately provide tailored proteins and related functional polymers on demand.